Biology – Quantitative Biology – Molecular Networks
Scientific paper
2008-03-10
Biology
Quantitative Biology
Molecular Networks
4 pages, 3 figures
Scientific paper
10.1103/PhysRevLett.101.268102
We consider two types of fluctuations in the mass-action equilibrium in protein binding networks. The first type is driven by relatively slow changes in total concentrations (copy numbers) of interacting proteins. The second type, to which we refer to as spontaneous, is caused by quickly decaying thermodynamic deviations away from the equilibrium of the system. As such they are amenable to methods of equilibrium statistical mechanics used in our study. We investigate the effects of network connectivity on these fluctuations and compare them to their upper and lower bounds. The collective effects are shown to sometimes lead to large power-law distributed amplification of spontaneous fluctuations as compared to the expectation for isolated dimers. As a consequence of this, the strength of both types of fluctuations is positively correlated with the overall network connectivity of proteins forming the complex. On the other hand, the relative amplitude of fluctuations is negatively correlated with the abundance of the complex. Our general findings are illustrated using a real network of protein-protein interactions in baker's yeast with experimentally determined protein concentrations.
Maslov Sergei
Walker Dylan
Yan Koon-Kiu
No associations
LandOfFree
Fluctuations in Mass-Action Equilibrium of Protein Binding Networks does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Fluctuations in Mass-Action Equilibrium of Protein Binding Networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluctuations in Mass-Action Equilibrium of Protein Binding Networks will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-379334