Physics – Biological Physics
Scientific paper
2002-01-16
Physics
Biological Physics
12 pages. Contribution to the proceedings of the International Workshop ``Modelling Bio-medical signals'', Bari, September 200
Scientific paper
We discuss two new approaches to extract relevant biological information on the Transcription Factors (and in particular to identify their binding sequences) from the statistical distribution of oligonucleotides in the upstream region of the genes. Both the methods are based on the notion of a ``regulatory network'' responsible for the various expression patterns of the genes. In particular we concentrate on families of coregulated genes and look for the simultaneous presence in the upstream regions of these genes of the same set of transcription factor binding sites. We discuss two instances which well exemplify the features of the two methods: the coregulation of glycolysis in Drosophila melanogaster and the diauxic shift in Saccharomyces cerevisiae.
Caselle Michele
Cunto Ferdinando Di
Pellegrino M.
Provero Paolo
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