Physics – Optics
Scientific paper
Feb 2011
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2011spie.7925e...5g&link_type=abstract
Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XI. Edited by Heisterkamp, Alexander; Neev,
Physics
Optics
Scientific paper
This paper aims at presenting a review of work at the Laser Thermal Laboratory on the microscopic laser modification of biological materials using ultrafast laser pulses. We have devised a new method for fabricating high aspect ratio patterns of varying height by using two-photon polymerization process in order to study contact guidance and directed growth of biological cells. Studies using NIH-3T3 and MDCK cells indicate that cell morphology on fiber scaffolds is influenced by the pattern of actin microfilament bundles. Cells experienced different strength of contact guidance depending on the ridge height. Cell morphology and motility was investigated on micronscale anisotropic cross patterns and parallel line patterns having different aspect ratios. A significant effect on cell alignment and directionality of migration was observed. Cell morphology and motility were influenced by the aspect ratio of the cross pattern, the grid size, and the ridge height. Cell contractility was examined microscopically in order to measure contractile forces generated by individual cells on self-standing fiber scaffolds.
Grigoropoulos Costas P.
Hidai Hirofumi
Hwang David J.
Jeon Hojeong
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