Facilitated diffusion of DNA-binding proteins: Efficient simulation with the method of excess collisions (MEC)

Details Facilitated diffusion of DNA-binding proteins: Efficient simulation with the method of excess collisions (MEC) Facilitated diffusion of DNA-binding proteins: Efficient simulation with the method of excess collisions (MEC)

2005-10-15

arxiv.org/abs/physics/0510146v1

Physics

Biological Physics

7 pages, 2 figures

Scientific paper

10.1063/1.2178806

In this paper, a new method to efficiently simulate diffusion controlled second order chemical reactions is derived and applied to site-specific DNA-binding proteins. The protein enters a spherical cell and propagates via two competing modes, a free diffusion and a DNA-sliding mode, to search for its specific binding site in the center of the cell. There is no need for a straightforward simulation of this process. Instead, an alternative and exact approach is shown to be essentially faster than explicit random-walk simulations. The speed-up of this novel simulation technique is rapidly growing with system size.

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