Exponential sensitivity of noise-driven switching in genetic networks

Details Exponential sensitivity of noise-driven switching in genetic networks Exponential sensitivity of noise-driven switching in genetic networks

2007-11-15

arxiv.org/abs/0711.2497v2

Physical Biology 5, 026005 (2008)

Biology

Quantitative Biology

Molecular Networks

5 pages, 3 figures

Scientific paper

10.1088/1478-3975/5/2/026005

Cells are known to utilize biochemical noise to probabilistically switch between distinct gene expression states. We demonstrate that such noise-driven switching is dominated by tails of probability distributions and is therefore exponentially sensitive to changes in physiological parameters such as transcription and translation rates. However, provided mRNA lifetimes are short, switching can still be accurately simulated using protein-only models of gene expression. Exponential sensitivity limits the robustness of noise-driven switching, suggesting cells may use other mechanisms in order to switch reliably.

Affiliated with

Also associated with

No associations

Rating

Exponential sensitivity of noise-driven switching in genetic networks does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Exponential sensitivity of noise-driven switching in genetic networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Exponential sensitivity of noise-driven switching in genetic networks will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-3165