Exons, introns and DNA thermodynamics

Details Exons, introns and DNA thermodynamics Exons, introns and DNA thermodynamics

2004-09-29

arxiv.org/abs/q-bio/0409034v2

Phys. Rev. Lett. 94, 178101 (2005)

Biology

Quantitative Biology

Biomolecules

4 pages, 8 figures - Final version as published. See also Phys. Rev. Focus 15, story 17

Scientific paper

10.1103/PhysRevLett.94.178101

The genes of eukaryotes are characterized by protein coding fragments, the exons, interrupted by introns, i.e. stretches of DNA which do not carry any useful information for the protein synthesis. We have analyzed the melting behavior of randomly selected human cDNA sequences obtained from the genomic DNA by removing all introns. A clear correspondence is observed between exons and melting domains. This finding may provide new insights in the physical mechanisms underlying the evolution of genes.

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