Biology – Quantitative Biology – Molecular Networks
Scientific paper
2008-04-07
Phys. Rev. Lett. 101, 118104 (2008)
Biology
Quantitative Biology
Molecular Networks
Revised version, accepted for publication
Scientific paper
10.1103/PhysRevLett.101.118104
DNA inversion is an important mechanism by which bacteria and bacteriophage switch reversibly between phenotypic states. In such switches, the orientation of a short DNA element is flipped by a site-specific recombinase enzyme. We propose a simple model for a DNA inversion switch in which recombinase production is dependent on the switch state (orientational control). Our model is inspired by the fim switch in Escherichia coli. We present an exact analytical solution of the chemical master equation for the model switch, as well as stochastic simulations. Orientational control causes the switch to deviate from Poissonian behaviour: the distribution of times in the on state shows a peak and successive flip times are correlated.
Allen Rosalind J.
Evans Martin R.
Visco Paolo
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