Evolution of the genetic code. From the CG- to the CGUA-alphabet, from RNA double helix to DNA

Details Evolution of the genetic code. From the CG- to the CGUA-alphabet, from RNA double helix to DNA Evolution of the genetic code. From the CG- to the CGUA-alphabet, from RNA double helix to DNA

2008-05-05

arxiv.org/abs/0805.0484v1

Biology

Quantitative Biology

Biomolecules

19 pages, 7 tables

Scientific paper

A hypothesis of the evolution of the genetic code is proposed, the leading mechanism of which is the nucleotide spontaneous damage leading to AT-enrichment of the genome. The hypothesis accounts for stability of the genetic code towards point mutations, the presence of code dialects, emergence of stop codons, emergence of the DNA double helix and the symmetry of the genetic code table. The assumption of the originally triplet structure of the genetic code has been substantiated. A hypothesis concerning the primary structure of the first gene and the first protein has been proposed.

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