Evolution of Multispecificity in an Immune Network

Details Evolution of Multispecificity in an Immune Network Evolution of Multispecificity in an Immune Network

1999-06-24

arxiv.org/abs/chao-dyn/9906039v1

Nonlinear Sciences

Chaotic Dynamics

6 pages, 3 figures. latex. This paper was accepted to the Proceedings of 5th European Conference on Artificial Life

Scientific paper

Divergence in antigen response of the immune network is discussed, based on shape-space modelling. The present model extends the shape-space model by introducing the evolution of specificity of idiotypes. When the amount of external antigen increases, stability of the immune network changes and the network responds to the antigen. It is shown that specific and non-specific responses emerge as a function of antigen levels. A specific response is observed with a fixed point attractor, and a non-specific response is observed with a long-lived chaotic transient state of the lymphocyte population dynamics. The network topology also changes between these two states. The relevance of such a long-lived transient state is discussed with respect to immune function.

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