Biology – Quantitative Biology – Molecular Networks
Scientific paper
2009-06-22
Biosens. Bioelectron. 25, 695-701 (2009)
Biology
Quantitative Biology
Molecular Networks
Scientific paper
10.1016/j.bios.2009.08.014
Electrode-immobilized glucose-6-phosphate dehydrogenase is used to catalyze an enzymatic reaction which carries out the AND logic gate. This logic function is considered here in the context of biocatalytic processes utilized for the biocomputing applications for "digital" (threshold) sensing/actuation. We outline the response functions desirable for such applications and report the first experimental realization of a sigmoid-shape response in one of the inputs. A kinetic model is developed and utilized to evaluate the extent to which the experimentally realized gate is close to optimal.
Katz Evgeny
Melnikov Dmitriy
Pedrosa Valber
Pita Marcos
Privman Vladimir
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