Entropic contributions to the splicing process

Details Entropic contributions to the splicing process Entropic contributions to the splicing process

2009-01-29

arxiv.org/abs/0901.4701v2

Biology

Quantitative Biology

Biomolecules

15 pages, 6 figures. Extended version, accepted for publication in Physical Biology

Scientific paper

It has been recently argued that the depletion attraction may play an important role in different aspects of the cellular organization, ranging from the organization of transcriptional activity in transcription factories to the formation of the nuclear bodies. In this paper we suggest a new application of these ideas in the context of the splicing process, a crucial step of messanger RNA maturation in Eukaryotes. We shall show that entropy effects and the resulting depletion attraction may explain the relevance of the aspecific intron length variable in the choice of the splice-site recognition modality. On top of that, some qualitative features of the genome architecture of higher Eukaryotes can find an evolutionary realistic motivation in the light of our model.

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