Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

Physics – Biological Physics

Scientific paper

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6 pages, 3 figures

Scientific paper

We show that a simple biophysically based electron-conformational model of
RyR channel is able to explain and describe on equal footing the oscillatory
regime of the heart's cell release unit both in sinoatrial node (pacemaker)
cells under normal physiological conditions and in ventricular myocytes under
Ca$^{2+}$ SR overload.

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