Elastic Network Models: Theoretical and Empirical Foundations

Details Elastic Network Models: Theoretical and Empirical Foundations Elastic Network Models: Theoretical and Empirical Foundations

2011-02-11

arxiv.org/abs/1102.2402v1

Biology

Quantitative Biology

Biomolecules

26 pages, 1 Figure

Scientific paper

Fifteen years ago Monique Tirion showed that the low-frequency normal modes of a protein are not significantly altered when non-bonded interactions are replaced by Hookean springs, for all atom pairs whose distance is smaller than a given cutoff value. Since then, it has been shown that coarse-grained versions of Tirion's model are able to provide fair insights on many dynamical properties of biological macromolecules. In this text, theoretical tools required for studying these so-called Elastic Network Models are described, focusing on practical issues and, in particular, on possible artifacts. Then, an overview of some typical results that have been obtained by studying such models is given.

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