Efficient Metal-Ion Catalyzed Template-Directed Oligonucleotide Synthesis

Details Efficient Metal-Ion Catalyzed Template-Directed Oligonucleotide Synthesis Efficient Metal-Ion Catalyzed Template-Directed Oligonucleotide Synthesis

Jun 1980

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1980sci...208.1464l&link_type=abstract

Science, Volume 208, Issue 4451, pp. 1464-1465

Physics

21

Scientific paper

The Pb2+ and Zn2+ ions are efficient catalysts for the polycytidylic acid-directed polymerization of an activated guanylic acid derivative, guanosine 5'-phosphorimidazolide The products include oligomers of 30 to 40 units in length. The nucleotide residues are predominantly 2'-5' linked when Pb2+ is the catalyst, and predominantly 3'-5' linked in the presence of Zn2+. The significance of these results in the context of the prebiotic evolution of RNA polymerase is discussed.

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