Biology – Quantitative Biology – Molecular Networks
Scientific paper
2006-11-22
physical biology 4, 164-171 (2007)
Biology
Quantitative Biology
Molecular Networks
7 figures. More discussion added
Scientific paper
10.1088/1478-3975/4/3/003
We build a simple model for feedback systems involving small RNA (sRNA) molecules based on the iron metabolism system in the bacterium E. coli, and compare it with the corresponding system in H. pylori which uses purely transcriptional regulation. This reveals several unique features of sRNA based regulation that could be exploited by cells. Firstly, we show that sRNA regulation can maintain a smaller turnover of target mRNAs than transcriptional regulation, without sacrificing the speed of response to external shocks. Secondly, we propose that a single sRNA can prioritize the usage of different target mRNAs. This suggests that sRNA regulation would be more common in more complex systems which need to co-regulate many mRNAs efficiently.
Andersson Anna M. C.
Krishna Sandeep
Mitarai Namiko
Semsey Szabolcs
Sneppen Kim
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