Effects of confinement and crowding on folding of model proteins

Details Effects of confinement and crowding on folding of model proteins Effects of confinement and crowding on folding of model proteins

2008-11-27

arxiv.org/abs/0811.4581v1

Biosystems. 2008 Dec;94(3):248-52

Biology

Quantitative Biology

Biomolecules

Scientific paper

10.1016/j.biosystems.2008.06.016

We perform molecular dynamics simulations for a simple coarse-grained model of crambin placed inside of a softly repulsive sphere of radius R. The confinement makes folding at the optimal temperature slower and affects the folding scenarios, but both effects are not dramatic. The influence of crowding on folding are studied by placing several identical proteins within the sphere, denaturing them, and then by monitoring refolding. If the interactions between the proteins are dominated by the excluded volume effects, the net folding times are essentially like for a single protein. An introduction of inter-proteinic attractive contacts hinders folding when the strength of the attraction exceeds about a half of the value of the strength of the single protein contacts. The bigger the strength of the attraction, the more likely is the occurrence of aggregation and misfolding.

Affiliated with

Also associated with

No associations

Rating

Effects of confinement and crowding on folding of model proteins does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Effects of confinement and crowding on folding of model proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Effects of confinement and crowding on folding of model proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-232975