Effect of intense, ultrashort laser pulses on DNA plasmids in their native state: strand breakages induced by {\it in-situ} electrons

Details Effect of intense, ultrashort laser pulses on DNA plasmids in their native state: strand breakages induced by {\it in-situ} electrons Effect of intense, ultrashort laser pulses on DNA plasmids in their native state: strand breakages induced by {\it in-situ} electrons

2010-06-02

arxiv.org/abs/1006.0358v1

Physics

Biological Physics

Part of an invited paper presented at the 3rd International Symposium on Filamentation, 31 May - 5 June, 2010, Crete, Greece

Scientific paper

Single strand breaks are induced in DNA plasmids, pBR322 and pUC19, in aqueous media by intense ultrashort laser pulses (820 nm wavelength, 45 fs pulse duration, 1 kHz repetition rate) at intensities of 1-12 TW cm$^{-2}$. The intense laser radiation generates, {\it in situ}, electrons that induce transformation of supercoiled DNA into relaxed DNA. The extent of electron-mediated relaxation of DNA structure is quantified. Introduction of electron and radical scavengers inhibits DNA damage.

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