Early transcriptional response of human T-lymphocytes to microgravity conditions during MASER 9 vector flight

Details Early transcriptional response of human T-lymphocytes to microgravity conditions during MASER 9 vector flight Early transcriptional response of human T-lymphocytes to microgravity conditions during MASER 9 vector flight

Aug 2003

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2003esasp.530..243n&link_type=abstract

In: 16th ESA Symposium on European Rocket and Balloon Programmes and Related Research, 2 - 5 June 2003, Sankt Gallen, Switzerlan

Physics

Space Flight: Life Science

Scientific paper

We used cDNA microarray hybridization technology to monitor the transcriptional response of human T-lymphocytes to 5.5 minutes of microgravity during a MASER vector flight. We found that in T-lymphocytes from two different donors about 1-2% of the genes monitored show significant modulation in response to microgravity. Most of the modulations observed appear to be donor-dependent but the genes coding for the small cytokine A5 RANTES and the interleukin 10 receptor beta were found similarly modulated in the two different donors examined.

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