Early Biochemical Effects of an Organic Mercury Fungicide on Infants: ``Dose Makes the Poison''

Details Early Biochemical Effects of an Organic Mercury Fungicide on Infants: ``Dose Makes the Poison'' Early Biochemical Effects of an Organic Mercury Fungicide on Infants: ``Dose Makes the Poison''

Feb 1985

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1985sci...227..638g&link_type=abstract

Science, Volume 227, Issue 4687, pp. 638-640

Physics

Scientific paper

Phenylmercury absorbed through the skin from contaminated diapers affected urinary excretion in infants in Buenos Aires. The effects were reversible and quantitatively related to the concentration of urinary mercury. Excretion of γ -glutamyl transpeptidase, an enzyme in the brush borders of renal tubular cells, increased in a dose-dependent manner when mercury excretion exceeded a ``threshold'' value. Urine volume also increased but at a higher threshold with respect to mercury. The results support the threshold concept of the systemic toxicity of metals. γ -Glutamyl transpeptidase is a useful and sensitive marker for preclinical effects of toxic metals.

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