Dynamics of path aggregation in the presence of turnover

Details Dynamics of path aggregation in the presence of turnover Dynamics of path aggregation in the presence of turnover

2008-08-08

arxiv.org/abs/0808.1195v3

Europhys. Lett. 87, 20003 (2009)

Physics

Biological Physics

6 pages, 5 figures; changed the order of presentation, rewritten the abstract and introduction, changed the title, expanded di

Scientific paper

We investigate the slow time scales that arise from aging of the paths during the process of path aggregation. This is studied using Monte-Carlo simulations of a model aiming to describe the formation of fascicles of axons mediated by contact axon-axon interactions. The growing axons are represented as interacting directed random walks in two spatial dimensions. To mimic axonal turnover, random walkers are injected and whole paths of individual walkers are removed at specified rates. We identify several distinct time scales that emerge from the system dynamics and can exceed the average axonal lifetime by orders of magnitude. In the dynamical steady state, the position-dependent distribution of fascicle sizes obeys a scaling law. We discuss our findings in terms of an analytically tractable, effective model of fascicle dynamics.

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