Dynamics of force-induced DNA slippage

Details Dynamics of force-induced DNA slippage Dynamics of force-induced DNA slippage

2004-07-12

arxiv.org/abs/q-bio/0407017v2

Biology

Quantitative Biology

Biomolecules

revised version with minor changes as will be published in Phys. Rev. Lett

Scientific paper

10.1103/PhysRevLett.93.198102

We study the basepairing dynamics of DNA with repetitive sequences where local strand slippage can create, annihilate, and move bulge loops. Using an explicit theoretical model, we find a rich dynamical behavior as a function of an applied shear force f: reptation-like dynamics at f=f_c with a rupture time scaling as N^3 with its length N, drift-diffusion dynamics for f_c < f < f^*, and a dynamical transition to an unraveling mode of strand separation at f = f^*. We predict a viscoelastic behavior for periodic DNA with time and force scales that can be programmed into its sequence.

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