Biology – Quantitative Biology – Molecular Networks
Scientific paper
2003-12-08
Biophysical Journal 86, 2650-2659 (2004)
Biology
Quantitative Biology
Molecular Networks
Accepted for publication in the Biophysical Journal
Scientific paper
10.1016/S0006-3495(04)74321-0
Evolution has provided many organisms with sophisticated sensory systems that enable them to respond to signals in their environment. The response frequently involves alteration in the pattern of movement, such as the chemokinesis of the bacterium Escherichia coli, which swims by rotating its flagella. When rotated counterclockwise (CCW) the flagella coalesce into a propulsive bundle, producing a relatively straight ``run'', and when rotated clockwise (CW) they fly apart, resulting in a ``tumble'' which reorients the cell with little translocation. A stochastic process generates the runs and tumbles, and in a chemoeffector gradient runs that carry the cell in a favorable direction are extended. The overall structure of the signal transduction pathways is well-characterized in E. coli, but important details are still not understood. Only recently has a source of gain in the signal transduction network been identified experimentally, and here we present a mathematical model based on dynamic assembly of receptor teams that can explain this observation.
Albert Reka
Chiu Yu-wen
Othmer Hans G.
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