Duplication-divergence model of protein interaction network

Details Duplication-divergence model of protein interaction network Duplication-divergence model of protein interaction network

2004-11-30

arxiv.org/abs/q-bio/0411052v1

Phys. Rev. E 71, 061911 (2005)

Biology

Quantitative Biology

Molecular Networks

8 pages, 13 figures

Scientific paper

10.1103/PhysRevE.71.061911

We show that the protein-protein interaction networks can be surprisingly well described by a very simple evolution model of duplication and divergence. The model exhibits a remarkably rich behavior depending on a single parameter, the probability to retain a duplicated link during divergence. When this parameter is large, the network growth is not self-averaging and an average vertex degree increases algebraically. The lack of self-averaging results in a great diversity of networks grown out of the same initial condition. For small values of the link retention probability, the growth is self-averaging, the average degree increases very slowly or tends to a constant, and a degree distribution has a power-law tail.

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