DNA transport by a micromachined Brownian ratchet device

Details DNA transport by a micromachined Brownian ratchet device DNA transport by a micromachined Brownian ratchet device

1999-12-21

arxiv.org/abs/physics/9912043v2

Proc. Natl. Acad. Sci. USA 96(23): 13165-13169 (1999)

Physics

Biological Physics

Latex: 8 pages, 4 figures

Scientific paper

10.1073/pnas.96.23.13165

We have micromachined a silicon-chip device that transports DNA with a Brownian ratchet that rectifies the Brownian motion of microscopic particles. Transport properties for a DNA 50mer agree with theoretical predictions, and the DNA diffusion constant agrees with previous experiments. This type of micromachine could provide a generic pump or separation component for DNA or other charged species as part of a microscale lab-on-a-chip. A device with reduced feature size could produce a size-based separation of DNA molecules, with applications including the detection of single nucleotide polymorphisms.

Affiliated with

Also associated with

No associations

Rating

DNA transport by a micromachined Brownian ratchet device does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with DNA transport by a micromachined Brownian ratchet device, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA transport by a micromachined Brownian ratchet device will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-519382