DNA-psoralen: single-molecule experiments and first principles calculations

Details DNA-psoralen: single-molecule experiments and first principles calculations DNA-psoralen: single-molecule experiments and first principles calculations

2010-09-03

arxiv.org/abs/1009.0690v1

Applied Physics Letters Volume: 95 Issue: 25 Article Number: 253703, 2009

Physics

Biological Physics

9 pages, 4 figures in re-print format 3 pages, 4 figures in the published version

Scientific paper

10.1063/1.3276555

The authors measure the persistence and contour lengths of DNA-psoralen complexes, as a function of psoralen concentration, for intercalated and crosslinked complexes. In both cases, the persistence length monotonically increases until a certain critical concentration is reached, above which it abruptly decreases and remains approximately constant. The contour length of the complexes exhibits no such discontinuous behavior. By fitting the relative increase of the contour length to the neighbor exclusion model, we obtain the exclusion number and the intrinsic intercalating constant of the psoralen-DNA interaction. Ab initio calculations are employed in order to provide an atomistic picture of these experimental findings.

Affiliated with

Also associated with

No associations

Rating

DNA-psoralen: single-molecule experiments and first principles calculations does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with DNA-psoralen: single-molecule experiments and first principles calculations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA-psoralen: single-molecule experiments and first principles calculations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-685018