DNA looping: the consequences and its control

Details DNA looping: the consequences and its control DNA looping: the consequences and its control

2006-09-26

arxiv.org/abs/q-bio/0609045v1

Curr. Opin. Struct. Biol. 16, 344-350 (2006)

Biology

Quantitative Biology

Biomolecules

Scientific paper

10.1016/j.sbi.2006.05.008

The formation of DNA loops by proteins and protein complexes is ubiquitous to many fundamental cellular processes, including transcription, recombination, and replication. Here we review recent advances in understanding the properties of DNA looping in its natural context and how they propagate to the cellular behavior through gene regulation. The results of connecting the molecular properties with cellular physiology indicate that looping of DNA in vivo is much more complex and easier than predicted from current models and reveals a wealth of previously unappreciated details.

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