Determination of barrier heights and prefactors from protein folding rate data

Details Determination of barrier heights and prefactors from protein folding rate data Determination of barrier heights and prefactors from protein folding rate data

2005-02-12

arxiv.org/abs/q-bio/0502011v1

Biology

Quantitative Biology

Biomolecules

11 pages, 5 figures, 1 table, Accepted Biophys J

Scientific paper

10.1529/biophysj.104.052548

We determine both barrier heights and prefactors for protein folding by applying constraints determined from experimental rate measurements to a Kramers theory for folding rate. The theoretical values are required to match the experimental values at two conditions of temperature and denaturant that induce the same stability. Several expressions for the prefactor in the Kramers rate equation are examined: a random energy approximation, a correlated energy approximation, and an approximation using a single Arrhenius activation energy. Barriers and prefactors are generally found to be large as a result of implementing this recipe, i.e. the folding landscape is cooperative and smooth. Interestingly, a prefactor with a single Arrhenius activation energy admits no formal solution.

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