Physics
Scientific paper
May 2003
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2003nimpb.206..553w&link_type=abstract
Nuclear Instruments and Methods in Physics Research Section B, Volume 206, p. 553-556.
Physics
Scientific paper
Investigating the biological effects of high-LET heavy ion irradiation at low fluence is important to evaluate the risk of charged particles. Especially it is important to detect radiation damage induced by the precise number of heavy ions in the individual cells. Thus we studied the relationship between the number of ions traversing the cell and DNA damage produced by the ion irradiation. We applied comet assay to measure the DNA damage in the individual cells. Cells attached on the ion track detector CR-39 were irradiated with ion beams at TIARA, JAERI-Takasaki. After irradiation, the cells were stained with ethidium bromide and the opposite side of the CR-39 was etched. We observed that the heavy ions with higher LET values induced the heavier DNA damage. The result indicated that the amount of DNA damage induced by one particle increased with the LET values of the heavy ions.
Funayama Tomoo
Ito Nobuyasu
Kobayashi Yasuaki
Natsuhori M.
Wada Shohei
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