Design of a folding inhibitor of the HIV-1 Protease

Details Design of a folding inhibitor of the HIV-1 Protease Design of a folding inhibitor of the HIV-1 Protease

2004-08-16

arxiv.org/abs/q-bio/0408013v1

Biology

Quantitative Biology

Biomolecules

Scientific paper

Being HIV-1-PR an essential enzyme in the viral life cycle, its inhibition can control AIDS. Because the folding of single domain proteins, like HIV-1-PR is controlled by local elementary structures (LES, folding units stabilized by strongly interacting, highly conserved amino acids) which have evolved over myriads of generations to recognize and strongly attract each other so as to make the protein fold fast, we suggest a novel type of HIV-1-PR inhibitors which interfere with the folding of the protein: short peptides displaying the same amino acid sequence of that of LES. Theoretical and experimental evidence for the specificity and efficiency of such inhibitors are presented.

Affiliated with

Also associated with

No associations

Rating

Design of a folding inhibitor of the HIV-1 Protease does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Design of a folding inhibitor of the HIV-1 Protease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Design of a folding inhibitor of the HIV-1 Protease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-580229