Desensitization of a balance with Langmuir binding of weights

Details Desensitization of a balance with Langmuir binding of weights Desensitization of a balance with Langmuir binding of weights

2003-03-13

arxiv.org/abs/physics/0303055v1

Physics

Biological Physics

11 pages with 3 embedded figures

Scientific paper

A balance is described with Langmuir binding of weights to each side. This simple physical system, when coupled with a previously derived equation for the equivalent displacement of weight that perturbs the equilibrium of a balance, models two-state, receptor systems in pharmacology for receptor activation. Surprisingly, this system also shows desensitization similar to many drug-receptor systems. Although understanding the biophysics behind receptor signaling is an important endeavor by itself, this analogy with a simple balance may bring new insights into other areas of physics as well.

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