Physics – Optics
Scientific paper
Jul 1997
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1997spie.3115..254w&link_type=abstract
Proc. SPIE Vol. 3115, p. 254-262, Hard X-Ray and Gamma-Ray Detector Physics, Optics, and Applications, Richard B. Hoover; F. Pat
Physics
Optics
Scientific paper
We report on the development of a high resolution radiation imaging system which is capable of detecting and imaging the coincident gamma and x-ray emissions of the radioisotope iodine 125 ((superscript 125)I). Iodine 125 is commonly available as a label to molecular biology probes. Iodine 125 decays via electron capture emitting a 35 keV gamma-ray with the prompt emission of several 27 - 32 keV x rays. A coincidence condition can be set to detect the (superscript 125)I decays thus reducing background radiation contribution to the image. We are testing the use of arrays of CsI(Na) crystal scintillators coupled to position sensitive photomultiplier tubes for this application. Laboratory studies have thus far been done on mice using a prototype of our detector which is intended to be used to image gene expression in live mice to advance research in neurobiology.
Bradley Eric
Majewski Stan
Saha Margaret
Weisenberger Andrew G.
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