Convergent dynamics in the protease enzymatic superfamily

Details Convergent dynamics in the protease enzymatic superfamily Convergent dynamics in the protease enzymatic superfamily

2006-09-15

arxiv.org/abs/q-bio/0609025v1

J. Am. Chem. Soc. 128, 9766-9772 (2006)

Biology

Quantitative Biology

Biomolecules

13 pages, 6 figures

Scientific paper

10.1021/ja060896t

Proteases regulate various aspects of the life cycle in all organisms by cleaving specific peptide bonds. Their action is so central for biochemical processes that at least 2% of any known genome encodes for proteolytic enzymes. Here we show that selected proteases pairs, despite differences in oligomeric state, catalytic residues and fold, share a common structural organization of functionally relevant regions which are further shown to undergo similar concerted movements. The structural and dynamical similarities found pervasively across evolutionarily distant clans point to common mechanisms for peptide hydrolysis.

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