Comments on "Remeasuring the Double Helix"

Details Comments on "Remeasuring the Double Helix" Comments on "Remeasuring the Double Helix"

2009-04-17

arxiv.org/abs/0904.2678v1

Biology

Quantitative Biology

Biomolecules

4 pages, 1 figure

Scientific paper

Mathew-Fenn et al. (Science (2008) 322, 446-9) measured end-to-end distances of short DNA and concluded that stretching fluctuations in several consecutive turns of the double helix should be strongly correlated. I argue that this conclusion is based on incorrect assumptions, notably, on a simplistic treatment of the excluded volume effect of reporter labels. Contrary to the author's claim, their conclusion is not supported by other data.

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