Comment on "Regularizing capacity of metabolic networks"

Details Comment on "Regularizing capacity of metabolic networks" Comment on "Regularizing capacity of metabolic networks"

2007-05-28

arxiv.org/abs/0705.4084v2

Phys. Rev. E 77, 023901 (2008)

Biology

Quantitative Biology

Molecular Networks

Scientific paper

10.1103/PhysRevE.77.023901

In a recent paper, Marr, Muller-Linow and Hutt [Phys. Rev. E 75, 041917 (2007)] investigate an artificial dynamic system on metabolic networks. They find a less complex time evolution of this dynamic system in real networks, compared to networks of reference models. The authors argue that this suggests that metabolic network structure is a major factor behind the stability of biochemical steady states. We reanalyze the same kind of data using a dynamic system modeling actual reaction kinetics. The conclusions about stability, from our analysis, are inconsistent with those of Marr et al. We argue that this issue calls for a more detailed type of modeling.

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