Coarse-grained lattice model for investigating the role of cooperativity in molecular recognition

Details Coarse-grained lattice model for investigating the role of cooperativity in molecular recognition Coarse-grained lattice model for investigating the role of cooperativity in molecular recognition

2008-01-07

arxiv.org/abs/0801.0959v1

Phys. Rev. E 76, 031914 (2007)

Physics

Biological Physics

12 pages, 7 figures

Scientific paper

10.1103/PhysRevE.76.031914

Equilibrium aspects of molecular recognition of rigid biomolecules are investigated using coarse-grained lattice models. The analysis is carried out in two stages. First an ensemble of probe molecules is designed with respect to the target biomolecule. The recognition ability of the probe ensemble is then investigated by calculating the free energy of association. The influence of cooperative and anti-cooperative effects accompanying the association of the target and probe molecules is studied. Numerical findings are presented and compared to analytical results which can be obtained in the limit of dominating cooperativity and in the mean-field formulation of the models.

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