Charge fluctuations and their effect on conduction in biological ion channels

Details Charge fluctuations and their effect on conduction in biological ion channels Charge fluctuations and their effect on conduction in biological ion channels

2008-07-05

arxiv.org/abs/0807.0838v1

Physics

Biological Physics

Conference, UPON2008, 14 pages

Scientific paper

10.1088/1742-5468/2009/01/P01010

The effect of fluctuations on the conductivity of ion channels is investigated. It is shown that modulation of the potential barrier at the selectivity site due to electrostatic amplification of charge fluctuations at the channel mouth exerts a leading-order effect on the channel conductivity. A Brownian dynamical model of ion motion in a channel is derived that takes into account both fluctuations at the channel mouth and vibrational modes of the wall. The charge fluctuations are modeled as a short noise flipping the height of the potential barrier. The wall fluctuations are introduced as a slow vibrational mode of protein motion that modulates ion conductance both stochastically and periodically. The model is used to estimate the contribution of the electrostatic amplification of charge fluctuations to the conductivity of ion channels.

Affiliated with

Also associated with

No associations

Rating

Charge fluctuations and their effect on conduction in biological ion channels does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Charge fluctuations and their effect on conduction in biological ion channels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Charge fluctuations and their effect on conduction in biological ion channels will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-447892