Cell-Penetrating Peptides, Electroporation, and Drug Delivery

Details Cell-Penetrating Peptides, Electroporation, and Drug Delivery Cell-Penetrating Peptides, Electroporation, and Drug Delivery

2010-09-19

arxiv.org/abs/1009.3606v1

IET Syst.\ Biol. 4 (2010) 367

Biology

Quantitative Biology

Biomolecules

11 pages, 5 figures

Scientific paper

10.1049/iet-syb.2010.0007

Certain short polycations, such as TAT and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis. These cell-penetrating peptides (CPPs) can carry with them cargos of 30 amino acids, more than the nominal limit of 500 Da and enough to be therapeutic. An analysis of the electrostatics of a charge outside the cell membrane and some recent experiments suggest that transduction may proceed by molecular electroporation. Ways to target diseased cells, rather than all cells, are discussed.

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