Biology – Quantitative Biology – Molecular Networks
Scientific paper
2007-12-21
Cellular and Molecular Life Sciences (CMLS), 64:1752-1762, 2007
Biology
Quantitative Biology
Molecular Networks
More similar papers at http://www.bri.nrc.ca/wang
Scientific paper
Genomic alterations lead to cancer complexity and form a major hurdle for a comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe the recent advances in studying cancer-associated genes from a systems biological point of view. The integration of known cancer genes onto protein and signaling networks reveals the characteristics of cancer genes within networks. This approach shows that cancer genes often function as network hub proteins which are involved in many cellular processes and form focal nodes in the information exchange between many signaling pathways. Literature mining allows constructing gene-gene networks, in which new cancer genes can be identified. The gene expression profiles of cancer cells are used for reconstructing gene regulatory networks. By doing so, the genes, which are involved in the regulation of cancer progression, can be picked up from these networks after which their functions can be further confirmed in the laboratory.
Lenferink Anne
O'Connor-McCourt Maureen
Wang Edwin
No associations
LandOfFree
Cancer systems biology: exploring cancer-associated genes on cellular networks does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Cancer systems biology: exploring cancer-associated genes on cellular networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cancer systems biology: exploring cancer-associated genes on cellular networks will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-697051