Physics – Biological Physics
Scientific paper
2003-02-12
Physics
Biological Physics
8 pages, 4 figures
Scientific paper
What determines the caliber of axonal branches? We pursue the hypothesis that the axonal caliber has evolved to minimize signal propagation delays, while keeping arbor volume to a minimum. We show that for a general cost function the optimal diameters of mother ($d_0$) and daughter ($d_1$, $d_2$) branches at a bifurcation obey a branching law: $d_{0}^{\nu+2}=d_{1}^{\nu+2} + d_{2}^{\nu+2}$. The derivation relies on the fact that the conduction speed scales with the axon diameter to the power $\nu$ ($\nu=1$ for myelinated axons and $\nu=0.5$ for non-myelinated axons). We test the branching law on the available experimental data and find a reasonable agreement.
Chklovskii Dmitri B.
Stepanyants Armen
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