Boolean versus continuous dynamics on simple two-gene modules

Details Boolean versus continuous dynamics on simple two-gene modules Boolean versus continuous dynamics on simple two-gene modules

2010-06-14

arxiv.org/abs/1006.2752v1

Biology

Quantitative Biology

Molecular Networks

8 pages, 10 figures

Scientific paper

We investigate the dynamical behavior of simple modules composed of two genes with two or three regulating connections. Continuous dynamics for mRNA and protein concentrations is compared to a Boolean model for gene activity. Using a generalized method, we study within a single framework different continuous models and different types of regulatory functions, and establish conditions under which the system can display stable oscillations. These conditions concern the time scales, the degree of cooperativity of the regulating interactions, and the signs of the interactions. Not all models that show oscillations under Boolean dynamics can have oscillations under continuous dynamics, and vice versa.

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