Bioinformatics analysis of experimentally determined protein complexes in the yeast, S. cerevisiae

Details Bioinformatics analysis of experimentally determined protein complexes in the yeast, S. cerevisiae Bioinformatics analysis of experimentally determined protein complexes in the yeast, S. cerevisiae

2003-10-10

arxiv.org/abs/q-bio/0310012v1

Biology

Quantitative Biology

Molecular Networks

Supplementary Material available at http://www.nd.edu/~networks

Scientific paper

Many important cellular functions are implemented by protein complexes that act as sophisticated molecular machines of varying size and temporal stability. Here we demonstrate quantitatively that protein complexes in the yeast, Saccharomyces cerevisiae, are comprised of a core in which subunits are highly coexpressed, display the same deletion phenotype (essential or non-essential) and share identical functional classification and cellular localization. This core is surrounded by a functionally mixed group of proteins, which likely represent short-lived- or spurious attachments. The results allow us to define the deletion phenotype and cellular task of most known complexes, and to identify with high confidence the biochemical role of hundreds of proteins with yet unassigned functionality.

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