Base sequence dependent sliding of proteins on DNA

Details Base sequence dependent sliding of proteins on DNA Base sequence dependent sliding of proteins on DNA

2004-03-19

arxiv.org/abs/q-bio/0403028v1

Phys. Rev. E 70, 041901 (2004)

Biology

Quantitative Biology

Biomolecules

12 pages, 3 figures

Scientific paper

10.1103/PhysRevE.70.041901

The possibility that the sliding motion of proteins on DNA is influenced by the base sequence through a base pair reading interaction, is considered. Referring to the case of the T7 RNA-polymerase, we show that the protein should follow a noise-influenced sequence-dependent motion which deviate from the standard random walk usually assumed. The general validity and the implications of the results are discussed.

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