Assembly Models for Papovaviridae based on Tiling Theory

Biology – Quantitative Biology – Biomolecules

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Scientific paper

10.1088/1478-3975/2/3/005

A vital constituent of a virus is its protein shell, called the viral capsid, that encapsulates and hence provides protection for the viral genome. Assembly models are developed for viral capsids built from protein building blocks that can assume different local bonding structures in the capsid. This situation occurs, for example, for viruses in the family of Papovaviridae, which are linked to cancer and are hence of particular interest for the health sector. More specifically, the viral capsids of the (pseudo-) T=7 particles in this family consist of pentamers that exhibit two different types of bonding structures. While this scenario cannot be described mathematically in terms of Caspar-Klug Theory (Caspar and Klug 1962), it can be modelled via tiling theory (Twarock 2004). The latter is used to encode the local bonding environment of the building blocks in a combinatorial structure, called the assembly tree, which is a basic ingredient in the derivation of assembly models for Papovaviridae along the lines of the equilibrium approach of Zlotnick (Zlotnick 1994). A phase space formalism is introduced to characterize the changes in the assembly pathways and intermediates triggered by the variations in the association energies characterizing the bonds between the building blocks in the capsid. Furthermore, the assembly pathways and concentrations of the statistically dominant assembly intermediates are determined. The example of Simian Virus 40 is discussed in detail.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Assembly Models for Papovaviridae based on Tiling Theory does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Assembly Models for Papovaviridae based on Tiling Theory, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assembly Models for Papovaviridae based on Tiling Theory will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-462773

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.