Aspiration of biological viscoelastic drops

Details Aspiration of biological viscoelastic drops Aspiration of biological viscoelastic drops

2010-03-23

arxiv.org/abs/1003.4372v1

Physics

Biological Physics

4 pages, 4 figures.

Scientific paper

Spherical cellular aggregates are in vitro systems to study the physical and biophysical properties of tissues. We present a novel approach to characterize the mechanical properties of cellular aggregates using micropipette aspiration technique. We observe an aspiration in two distinct regimes, a fast elastic deformation followed by a viscous flow. We develop a model based on this viscoelastic behavior to deduce the surface tension, viscosity, and elastic modulus. A major result is the increase of the surface tension with the applied force, interpreted as an effect of cellular mechanosensing.

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