Application of Pixel Detectors in Structural Biology

Physics – Medical Physics

Scientific paper

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Scientific paper

Silicon pixel detectors (both hybrid and active pixel sensors), are potentially useful for electron microscopy and x-ray crystallography. By direct detection of x-rays or electrons, these detectors eliminate the intermediate step of light conversion required by CCDs, which reduces the spatial resolution. Pixel detectors offer excellent spatial resolution, high efficiency and fast readout speeds. The main emphasis of this review is on electron detection in the context of electron microscopy with a brief section on x-ray crystallography.

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