Antitumour Activity of Iodine in Acidic Medium with Calcium

Details Antitumour Activity of Iodine in Acidic Medium with Calcium Antitumour Activity of Iodine in Acidic Medium with Calcium

Nov 1973

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1973natur.246...98v&link_type=abstract

Nature, Volume 246, Issue 5428, pp. 98-100 (1973).

Physics

14

Scientific paper

THE basal metabolism is increased in many patients with lymphatic and myelogenous leukaemia. Elevated levels of plasma iodine have been found in various leukaemic cases, possibly indicating involvement of the thyroid gland1. It is thought that at lower pH values there is more free iodine, and so greater penetrability into cells and greater iodine activity2. Iodine fixation by human leukocytes requires energy3. Iodine alters the redox state of the cytoplasm and mitochondria, because the couple 2 I--->I2+2 e has a rather high redox potential: +0.535 V; iodine seems to be one of the oxidizing agents which can be used for ATP formation4. Flavin is the most likely oxidizing agent for a couple with such a high redox potential5.

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