Analytical study of the effect of recombination on evolution via DNA shuffling

Details Analytical study of the effect of recombination on evolution via DNA shuffling Analytical study of the effect of recombination on evolution via DNA shuffling

2003-03-28

arxiv.org/abs/physics/0303120v1

Physics

Biological Physics

Scientific paper

10.1103/PhysRevE.69.051911

We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination and point mutations. The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population. We also briefly discuss finite population size corrections.

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