Analytic models for mechanotransduction: gating a mechanosensitive channel

Details Analytic models for mechanotransduction: gating a mechanosensitive channel Analytic models for mechanotransduction: gating a mechanosensitive channel

2003-11-10

arxiv.org/abs/q-bio/0311010v1

Biology

Quantitative Biology

Biomolecules

Scientific paper

10.1073/pnas.0307804101

Analytic estimates for the forces and free energy generated by bilayer deformation reveal a compelling and intuitive model for MscL channel gating analogous to the nucleation of a second phase. We argue that the competition between hydrophobic mismatch and tension results in a surprisingly rich story which can provide both a quantitative comparison to measurements of opening tension for MscL when reconstituted in bilayers of different thickness and qualitative insights into the function of the MscL channel and other transmembrane proteins.

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