Physics – Biological Physics
Scientific paper
2003-04-21
Physics
Biological Physics
14 pages, 10 figures. A few changes in section IV and addition of a new figure
Scientific paper
10.1103/PhysRevE.69.011907
The influx of calcium ions into the dendritic spines through the N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for various forms of synaptic plasticity. In this paper, the authors calculate analytically the mean values of the calcium transients elicited by a spiking neuron undergoing a simple model of ionic currents and back-propagating action potentials. The relative variability of these transients, due to the stochastic nature of synaptic transmission, is further considered using a simple Markov model of NMDA receptos. One finds that both the mean value and the variability depend on the timing between pre- and postsynaptic action-potentials. These results could have implications on the expected form of synaptic-plasticity curve and can form a basis for a unified theory of spike time-dependent, and rate based plasticity.
Castellani Gastone C.
Shouval Harel Z.
Yeung Luk C.
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