Analog Noise Reduction in Enzymatic Logic Gates

Details Analog Noise Reduction in Enzymatic Logic Gates Analog Noise Reduction in Enzymatic Logic Gates

2009-05-17

arxiv.org/abs/0905.2714v1

J. Phys. Chem. B 113, 10472-10479 (2009)

Biology

Quantitative Biology

Molecular Networks

25 pages in PDF

Scientific paper

10.1021/jp904585x

In this work we demonstrate both experimentally and theoretically that the analog noise generation by a single enzymatic logic gate can be dramatically reduced to yield gate operation with virtually no input noise amplification. This is achieved by exploiting the enzyme's specificity when using a co-substrate that has a much lower affinity than the primary substrate. Under these conditions, we obtain a negligible increase in the noise output from the logic gate as compared to the input noise level. Experimental realizations of the AND logic gate with the enzyme horseradish peroxidase using hydrogen peroxide and two different co-substrates, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) and ferrocyanide, with vastly different rate constants confirmed our general theoretical conclusions.

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